ENHANCED EXTRACTION OF BLOOD AND TISSUE TIME-ACTIVITY CURVES IN CARDIAC MOUSE FDG PET IMAGING BY MEANS OF CONSTRAINED NONNEGATIVE MATRIX FACTORIZATION

We propose an enhanced method to accurately retrieve time-activity curves (TACs) of blood and tissue from dynamic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) positron emission tomography (PET) Benches cardiac images of mice.The method is noninvasive and consists of using a constrained nonnegative matrix factorization algorithm (CNMF) applied to the

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